The University of Pittsburgh’s Alzheimer’s Disease Research Center
In 2022, the Aging Mind Foundation awarded a $590,000 grant to The University of Pittsburgh’s Alzheimer’s Disease Research Center. The knowledge gained from this study will directly translate in clear benefits to the community and ascertain the association of astrogliosis with Alzheimer’s disease pathology, cerebrovascular disease, and neurodegeneration, which will provide critical knowledge for the design of future preventive strategies for Alzheimer’s disease. The research will be led by Dr. Victor L. Villamagne. Dr. Villamagne is recognized as one of “The World’s Most Influential Scientific Minds” based on his citations ranking in the top 1% globally in the field of Neuroscience and currently ranked #19 in the world among Alzheimer’s disease experts (2022).
The Cleveland Clinic Foundation
In 2021, the Aging Mind Foundation awarded a $300,000 grant to The Cleveland Clinic Foundation. The grant will fund research to identify and define key inflammatory factors that are active in the early stages of dementia. By conducting this research, they seek to bridge the knowledge gaps that exist and help characterize the early cause of dementia to better inform intervention strategies that target the immune response in dementia. The research study, Circulating Inflammatory Factors in Early Stage Dementia, will be led by Principal Investigator, Dr. Lynn Bekris, co-director of the Cleveland Clinic Lou Ruvo Center for Brain Health Aging and Neurodegeneration Biobank and Cleveland Alzheimer’s Disease Research Center Biomarker Core Director.
COLUMBIA MEDICAL SCHOOL’S ALZHEIMER’S DISEASE RESEARCH CENTER
In 2020, the Aging Mind Foundation awarded a $500,000 grant to Columbia Medical School’s Alzheimer’s Disease Research Center. The grant will fund research to investigate the cause of Cerebro-Spinal Fluid elevation of the protein Tau in Alzheimer Disease and to further research on the trafficking hypothesis. The research will be led by Dr. Scott Small.
YALE UNIVERSITY SCHOOL OF MEDICINE’S CELLULAR NEUROSCIENCE, NEURODEGENERATION AND REPAIR PROGRAM
In 2019, the Aging Mind Foundation awarded a $600,000 grant to Yale University School of Medicine’s Cellular Neuroscience, Neurodegeneration and Repair Program. The grant will fund research to develop therapeutic methods to protect synapses, the specialized connections between nerve cells, from Amyloid-beta triggered degeneration. Success will rescue the brain’s neural network from Alzheimer-associated damage without a need to remove or reduce Amyloid itself.
UNIVERSITY OF TEXAS SOUTHWESTERN (UTSW) CENTER FOR ALZHEIMER’S AND NEURODEGENERATIVE DISEASES
In 2018, the Aging Mind Foundation awarded a $700,000 grant to UTSW’s Center for Alzheimer’s and Neurodegenerative Diseases. This grant will fund research to identify molecular mechanisms and therapeutic targets that play a key role in the pathogenesis of disease. The research seeks to develop new therapies and diagnostics for Alzheimer’s that will allow diagnosis and treatment in people before the onset of cognitive problems.
Baylor AT&T Memory Center
In 2017, the Aging Mind Foundation awarded a $400,000 grant to Baylor AT&T Memory Center. A portion of this grant has been used to fund the TGen research project where Baylor AT&T Memory Center patient-physician researchers are partnering with TGen, a genomics research center, to conduct a gene sequencing study on “outlier” Alzheimer’s patients, which has not been done before. TGen’s previous research suggests that these patients may have rare genetic mutations in known Alzheimer’s disease genes. This study will be valuable because, until now, power analyses of this nature have only focused on patients who are high-risk and/or have a family history of Alzheimer’s disease and whose disease can be predicted because of a known genetic mutation.
The remaining portion of the grant was used to fund a research project led by Dr. Teodoro Bottiglieri to ascertain differences in metabolites between the normal brain and an Alzheimer’s disease brain to help identify affected pathways and lead to the possible development of targeted therapies.
Center for Brain Health
In 2016, the Aging Mind Foundation awarded a $220,000 grant to Center for Brain Health. This grant was used to focus on the exploration of cognitive behavior and other biomarkers found in early mild cognitive impairment participants by using experimental modalities through a three-year postdoctoral fellowship awarded to Dr. Namrata Singh. Her research interests include understanding the process and stages of dementia using advanced brain scans and other technologically advanced techniques.
Center for Vital Longevity
In 2015, the Aging Mind Foundation awarded a $208,950 grant to Center for Vital Longevity. This grant was used to support research to further advancements in the field of cognitive neuroscience of aging through a three-year postdoctoral fellowship awarded to Dr. Sara Festini. Dr. Festini’s research focuses on cognition and brain function in busy people versus people who are less active and more relaxed.